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- holgentech_at_gmail_dot_com) Big Pharma & Big IT might lead together Genome Business by means of Genome Editing to cure cancers (Facebook note by Andras Pellionisz) Once upon a time, there was the Axiom that "Atoms Do Not Split”.
Therefore, promoters are "invisible" when only the exomes of cells are sequenced, as has been commonplace in cancer genetics research."Promoters are important in determining when specific genes are turned on and off," says Feigin, "and I became interested in figuring out whether mutations within promoters -- as opposed to within the genes they regulate -consistently affects the way cancers develop and sustain themselves." The team "looked all across the genome," Feigin says, "and, interestingly, while we did find mutations in promoters, we never found clusters of these mutations near any of the genes that prior research had already told us were typically mutated in pancreatic cancer." Genes called KRAS and p53 are mutated in the majority of pancreas cancer cells, for example.But mutations in promoters sifted out of mountains of data by the team's novel mathematical formula, or algorithm, called GECCO, lay in genes never before implicated in pancreatic cancer.Feigin points out that mutations in a promoter can affect how much protein is generated by the gene its regulates.In this way these mutations are unlike those usually found in KRAS and p53, for example, which impair or otherwise alter the function of the proteins they encode.Any proposed explanation should therefore not only bridge the century-long historical gap, but also demonstrate why the VMs appears both ‘language-y’ and ‘cipher-y’ at the same time. From a code-breaker’s point of view, this basically rules out Renaissance polyalphabetic ciphers, because they use multiple alphabets (or offsets into alphabets) to destroy the outward signs of internal structure – and what we see here has even more signs of internal structure than normal languages.
To illustrate this, here are some practical examples of the way Voynichese letters ‘dance’ to a tricky set of structural rules. Yet just to be confusing, some of the letter-shapes resemble shorthand both in their shape and their apparent positioning within words. is ‘Voynichese’ a language, a shorthand, a cipher, or perhaps some carefully-orchestrated jumble of all three?Science enabled Leo Szilárd to patent the nuclear reactor for peaceful use.Leo Szilárd also suggested the first purchase of the less peaceful Manhattan Project.Right now, nobody can say – but perhaps it is this ‘hard-to-pin-down-ness’ that has managed to keep the Voynich’s mystery alive for all this time.(Jul 04) [Independence Day] A 27-year-old who worked for Apple as a teenager wants to make a yearly blood test to diagnose cancer and he just got .5 million from Silicon Valley VCs to pull it off (This portrait was taken a while ago ... What really counts is not when you explain for the first time something like Fracto Gene; "Fractal Genome Grows Fractal Organisms".Yes, there are countries (including a sub-Continent) trying to gain access to the IP, in order to get the green to the US oncogenomics market. Yes, since another genomic phenomenon was also visible (by the naked eye in Indian Corn) - but her breakthrough had to wait about 40 years.