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For example, AAS may prematurely stop the lengthening of bones (premature epiphyseal fusion through increased levels of estrogen metabolites), resulting in stunted growth.

AAS were synthesized in the 1930s, and are now used therapeutically in medicine to stimulate muscle growth and appetite, induce male puberty and treat chronic wasting conditions, such as cancer and .

Injection is the most common method used by individuals administering AAS for non-medical purposes.

The traditional routes of administration do not have differential effects on the efficacy of the drug.

Such use is prohibited by the rules of the governing bodies of most sports.

AAS use occurs among adolescents, especially by those participating in competitive sports. There are four common forms in which AAS are administered: oral pills; injectable steroids; creams/gels for topical application; and skin patches. Testosterone administered by mouth is rapidly absorbed, but it is largely converted to inactive metabolites, and only about one-sixth is available in active form.

Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed.

There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses.Injectable steroids are typically administered into the muscle, not into the vein, to avoid sudden changes in the amount of the drug in the bloodstream.In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism (clot) in the bloodstream.Studies indicate that the anabolic properties of AAS are relatively similar despite the differences in pharmacokinetic principles such as first-pass metabolism.However, the orally available forms of AAS may cause liver damage in high doses.Conditions pertaining to hormonal imbalances such as gynecomastia and testicular size reduction may also be caused by AAS.[citation needed] Ergogenic uses for AAS in sports, racing, and bodybuilding as performance-enhancing drugs are controversial because of their adverse effects and the potential to gain unfair advantage in physical competitions.